Thanks to his new apprentice Amanda, Jigsaw has escaped and eluded capture. While the police struggle to locate him, Dr. Lynn Denlon is unaware that she is about to become the latest player in one of his twisted games. One night, after finishing a shift at her hospital, Lynn is kidnapped and taken to an abandoned warehouse where she meets Jigsaw, bedridden and on the verge of death. She is told that she must keep the killer alive for as long as it takes another one of his victims, Jeff, to complete a game of his own. Racing against the ticking clock of Jigsaw's own heartbeat, Lynn and Jeff struggle to make it through each of their vicious tests, unaware that he has a much bigger plan for both of them.