This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both in vitro and in vivo; the links that have emerged between proteolysis and cell signalling; how the degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to targeting proteolysis for therapy.
| Title: | The Cancer Degradome: Proteases and Cancer Biology | Publisher: | Springer |
| Author: | Dylan Edwards, Gunilla Hoyer Hansen, Francesco Blasi |
| Edition: | Hardcover |
| Language: | English |
| ISBN: | 0387690565 |
| EAN: | 9780387690568 |
| No. of Pages: | 926 |
| Publish Date: | 2008-10-1 |
| Binding: | Hardcover |
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