This book will aim to cover recent knowledge of the composition of the Degradome, how it can be studied using modern approaches such as transcriptomics and mass spectrometry; how gene knockout mice have improved our knowledge of the roles of proteases in cancer; how their activity can be imaged both in vitro and in vivo; the links that have emerged between proteolysis and cell signalling; how the degradome can be a useful source of diagnostic and prognostic markers; and finally new approaches to targeting proteolysis for therapy.
|Title:||The Cancer Degradome: Proteases and Cancer Biology||Publisher:||Springer|
|Author:||Dylan Edwards, Gunilla Hoyer Hansen, Francesco Blasi|
|No. of Pages:||926|
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