|Publisher:||John Wiley & Sons|
|No. of Units:||1|
|No. of Pages:||677|
HELMUT GREIM, Institut fur Toxikologie und Umwelthygiene, Technische Universitat Munchen
ROBERT SNYDER, Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey
Toxicology is concerned with the health risks of human exposure to chemicals. It describes the adverse effects of chemicals in a qualitative sense, and with evaluating them quantitatively by determining how much of a chemical is required to produce a given response.
"Toxicology and Risk Assessment: A Comprehensive Introduction" describes the basic concepts of toxicology, and aims to equip the reader with the skills required to evaluate risks at given exposures. Topics covered include:
Principles in Toxicology: toxicokinetics including absorption, distribution, metabolism and excretion; the mechanisms that lead to cytotoxicity, carcinogenicity and effects on reproduction; and the toxic effects of mixtures of chemicals Organ Toxicology: information on anatomy and physiology of the major organs; why they are specific targets; and the mechanisms of specific chemicals affecting these organs Methods in Toxicology: the commonly used methods used for toxicity testing, both "in vivo" and "in vitro" Risk Assessment: the concepts comprising hazard identification, dose-response, and exposure assessment and the different approaches for thresholded and non-thresholded effects. Recent molecular-biological results on cellular responses to genotoxic agents such as DNA-repair, halt of proliferation, and apoptosis that allow assumption of thresholded genotoxic effects are also described Risk Management: US and Europeanregulations for chemicals Toxicity of Chemicals: the toxic mechanisms and effects of major groups of chemicals
"Toxicology and Risk Assessment" is an essential text for scientists in academia, industry and government agencies who want to understand how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios.
This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps.
In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections: Principles in Toxicology Organ Toxicology Methods in Toxicology Risk Assessment Risk Management Toxicity of Chemicals
Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.