This is an advanced clinical reference text on the pathogenesis, clinical aspects, and treatment of uterine fibroids in thirteen chapters by an international team of highly placed experts in obstetrics and gynecology, reproductive medicine and science, reproductive endocrinology, and pathology. The pathogenesis section focuses on uterine leiomyomas, including histogenesis, sex steroidal regulation, sex hormone action, growth factors, mesenchymal tumors, and group I proteins. The chapters on clinical aspects cover epidemiology, three-dimensional and color Doppler assessment, and clinicopathological features. Four chapters on medical therapy of uterine fibroids cover short-term therapy and gonadotropin-releasing hormone agonist, progestogens and antiestrogens, GnRH antagonists, and the role of RU 486 (Mifepristone) in uterine fibroid treatment. Includes bibliographic references and index.