Lignans as Anticancer Agents Lignans as Anticancer Agents

Lignans as Anticancer Agents (Paperback)

By Rajesh Kumar 
R 5,654
Publisher: LAP Lambert Academic Publishing
Edition: Paperback
ISBN: 3659182249
EAN: 9783659182242
No. of Units: 1
No. of Pages: 184
Publish Date: 2012-8-20
Binding: Paperback
Sold by Ingram ( Average Ratings: Rating of 4.2 out of 5 Rating of 4.2 out of 5 Rating of 4.2 out of 5 Rating of 4.2 out of 5 Rating of 4.2 out of 5 )
Sourcing Fee: R 678

Ships in 5 - 7 Days. ( FREE Shipping in India )
Ships to India.
Check Delivery to my Area

Description

Cancer, an abnormal and uncontrolled cell division, has engulfed the lives of unlimited people till date. Etoposide and Teniposide are podophyllotoxin derivatives and have been used clinically for treatment of refractory testicular tumor and cancer. These compounds arrests cell growth by DNA topo II inhibition, which causes double strand breaks in DNA and known as non-interclating topo II inhibitors. They have many side effects, such as myelosuppression, poor water solubility, and the development of resistance so modification is done on it at various sites. Podophyllotoxin contains a five-ring system. Modification of the A-ring gave compounds having significant activity but less than that of Etoposide, whereas modification of the B-ring resulted in the loss of activity. E-ring is essential for its anticancer activity and D-ring in lactone form is preferred for better activity. The introduction of double bond in C-ring lowers the activity but modifications at the C-4 in C-ring with bulkier groups enhance anticancer activity. NK-611, GL-331 and Etoposide phosphate are water soluble derivatives of Etoposide with potent anticancer activity and are currently in clinical trials.
show moreless

Specification

Title: Lignans as Anticancer Agents
Publisher: LAP Lambert Academic Publishing
Author: Rajesh Kumar
Edition: Paperback
ISBN: 3659182249
EAN: 9783659182242
No. of Units: 1
No. of Pages: 184
Publish Date: 2012-8-20
Binding: Paperback

Disclaimer

  • The book summary and image may be of a different edition or binding of the same title.
  • Book reviews are added by registered customers. They need not necessarily buy book.
  • These books are NOT available for reading online or for free download in PDF or ebook format.
  • Price can change due to reprinting, price change by publisher or sourcing cost change for imported books.
  • www.infibeam.com/Books is the biggest online bookstore in India for sale of books at best price - fiction, literature, audiobooks, study guides, novels, story books, rare books, textbooks and books by popular authors. These are available in various editions and bindings e.g. paperback and at best discount.
  • For the imported title, once the order gets placed ,it can’t be cancelled


Great Value

Safe Payment

Shop With
Confidence

24/7 Help Center

Free & Easy Return

Get Discounts & Offers
Stay Connected
Copyright © 2007-2017 Infibeam.com and Affiliates
Site is up